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EUROGIN 2011 roadmap on prevention and treatment of HPV‐related disease

Identifieur interne : 005693 ( Main/Exploration ); précédent : 005692; suivant : 005694

EUROGIN 2011 roadmap on prevention and treatment of HPV‐related disease

Auteurs : Marc Arbyn [Belgique] ; Silvia De Sanjosé [Espagne] ; Mona Saraiya [États-Unis] ; Mario Sideri [Italie] ; Joel Palefsky [États-Unis] ; Charles Lacey [Royaume-Uni] ; Maura Gillison [États-Unis] ; Laia Bruni [Espagne] ; Guglielmo Ronco [Italie] ; Nicolas Wentzensen [États-Unis] ; Julia Brotherton [Australie] ; You-Lin Qiao [République populaire de Chine] ; Lynnette Denny [Afrique du Sud] ; Jacob Bornstein [Israël] ; Laurent Abramowitz [France] ; Anna Giuliano [États-Unis] ; Massimo Tommasino [France] ; Joseph Monsonego [France]

Source :

RBID : ISTEX:935AB89958FC3A1F9DB2567B0815C31C7D57F289

Descripteurs français

English descriptors

Abstract

The EUROGIN 2011 roadmap reviews the current burden of human papillomavirus (HPV)‐related morbidity, as well as the evidence and potential practice recommendations regarding primary and secondary prevention and treatment of cancers and other disease associated with HPV infection. HPV infection causes ∼600,000 cases of cancer of the cervix, vulva, vagina, anus and oropharynx annually, as well as benign diseases such as genital warts and recurrent respiratory papillomatosis. Whereas the incidence of cervical cancer has been decreasing over recent decades, the incidence of anal and oropharyngeal carcinoma, for which there are no effective screening programs, has been rising over the last couple of decades. Randomized trials have demonstrated improved efficacy of HPV‐based compared to cytology‐based cervical cancer screening. Defining the best algorithms to triage HPV‐positive women, age ranges and screening intervals are priorities for pooled analyses and further research, whereas feasibility questions can be addressed through screening programs. HPV vaccination will reduce the burden of cervical precancer and probably also of invasive cervical and other HPV‐related disease in women. Recent trials demonstrated that prophylactic vaccination also protects against anogenital HPV infection, anogenital intraepithelial lesions and warts associated with vaccine types, in males; and anal HPV infection and anal intraepithelial neoplasia in MSM. HPV‐related oropharyngeal cancer could be treated less aggressively because of better survival compared to cancers of the oropharynx unrelated to HPV. Key findings in the field of cervical cancer prevention should now be translated in cost‐effective strategies, following an organized approach integrating primary and secondary prevention, according to scientific evidence but adapted to the local situation with particular attention to regions with the highest burden of disease.

Url:
DOI: 10.1002/ijc.27650


Affiliations:


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<term>Vaccination</term>
<term>Vaccination coverage</term>
<term>Vaccination policies</term>
<term>Vaccine</term>
<term>Vaccine types</term>
<term>Vulva</term>
<term>Vulva cancer</term>
<term>Vulvar</term>
<term>Vulvar cancer</term>
<term>Vulvar cancers</term>
<term>Whole country</term>
<term>Worldwide burden</term>
<term>Years years years</term>
<term>Young women</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Cancer anal</term>
<term>Cancer de la tête et du cou</term>
<term>Cancer de la vulve</term>
<term>Cancer du col de l'utérus</term>
<term>Cancer du pénis</term>
<term>Cancérologie</term>
<term>Condylome acuminé</term>
<term>Dépistage</term>
<term>Epidémiologie</term>
<term>Incidence</term>
<term>Mortalité</term>
<term>Papillomavirus humain</term>
<term>Prévention</term>
<term>Traitement</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en">
<term>Anal</term>
<term>Anal cancer</term>
<term>Anal cancers</term>
<term>Arbyn</term>
<term>Assay</term>
<term>Benign diseases</term>
<term>Biopsy</term>
<term>Cancer</term>
<term>Cancer epidemiology</term>
<term>Cancer prevention</term>
<term>Cancer screening</term>
<term>Cape town</term>
<term>Carcinogenic risks</term>
<term>Carcinoma</term>
<term>Cell carcinoma</term>
<term>Cervical</term>
<term>Cervical cancer</term>
<term>Cervical cancer prevention</term>
<term>Cervical cancer screening</term>
<term>Cervical histology</term>
<term>Cervical precancer</term>
<term>Clin</term>
<term>Clin pathol</term>
<term>Clinical practice</term>
<term>Clinical workshop</term>
<term>Common cancer</term>
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<term>Coverage report</term>
<term>Current burden</term>
<term>Cytology</term>
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<term>Disease control</term>
<term>Early effects</term>
<term>Effective screening programs</term>
<term>Engl</term>
<term>Epidemiology</term>
<term>Eurogin</term>
<term>European commission</term>
<term>Female partners</term>
<term>Further research</term>
<term>General population</term>
<term>Genit tract</term>
<term>Genital</term>
<term>Genital warts</term>
<term>Global burden</term>
<term>Grant funding</term>
<term>Grant number</term>
<term>High grade</term>
<term>Highest burden</term>
<term>Human cancers</term>
<term>Human papillomavirus</term>
<term>Human papillomavirus prevalence</term>
<term>Human papillomavirus testing</term>
<term>Human papillomaviruses</term>
<term>Iarc</term>
<term>Incidence</term>
<term>Incidence rates</term>
<term>Infection</term>
<term>International papillomavirus conference</term>
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<term>Invasive cancer</term>
<term>Lancet</term>
<term>Lancet oncol</term>
<term>Lancet oncol ronco</term>
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<term>Mini review</term>
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<term>Natl cancer inst</term>
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<term>Oropharyngeal</term>
<term>Oropharyngeal cancer</term>
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<term>Other disease</term>
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<term>Papillomavirus infection</term>
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<term>Several countries</term>
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<term>Squamous cell carcinoma</term>
<term>Squamous hyperplasias</term>
<term>Systematic review</term>
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<term>Uicc mini review</term>
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<term>Vaccination coverage</term>
<term>Vaccination policies</term>
<term>Vaccine</term>
<term>Vaccine types</term>
<term>Vulva</term>
<term>Vulvar</term>
<term>Vulvar cancer</term>
<term>Vulvar cancers</term>
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<term>Worldwide burden</term>
<term>Years years years</term>
<term>Young women</term>
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<term>Cancer</term>
<term>Cytologie</term>
<term>Mortalité</term>
<term>Vaccination</term>
<term>épidémiologie</term>
<term>Santé publique</term>
<term>Vaccination</term>
<term>Vaccin</term>
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<front>
<div type="abstract" xml:lang="en">The EUROGIN 2011 roadmap reviews the current burden of human papillomavirus (HPV)‐related morbidity, as well as the evidence and potential practice recommendations regarding primary and secondary prevention and treatment of cancers and other disease associated with HPV infection. HPV infection causes ∼600,000 cases of cancer of the cervix, vulva, vagina, anus and oropharynx annually, as well as benign diseases such as genital warts and recurrent respiratory papillomatosis. Whereas the incidence of cervical cancer has been decreasing over recent decades, the incidence of anal and oropharyngeal carcinoma, for which there are no effective screening programs, has been rising over the last couple of decades. Randomized trials have demonstrated improved efficacy of HPV‐based compared to cytology‐based cervical cancer screening. Defining the best algorithms to triage HPV‐positive women, age ranges and screening intervals are priorities for pooled analyses and further research, whereas feasibility questions can be addressed through screening programs. HPV vaccination will reduce the burden of cervical precancer and probably also of invasive cervical and other HPV‐related disease in women. Recent trials demonstrated that prophylactic vaccination also protects against anogenital HPV infection, anogenital intraepithelial lesions and warts associated with vaccine types, in males; and anal HPV infection and anal intraepithelial neoplasia in MSM. HPV‐related oropharyngeal cancer could be treated less aggressively because of better survival compared to cancers of the oropharynx unrelated to HPV. Key findings in the field of cervical cancer prevention should now be translated in cost‐effective strategies, following an organized approach integrating primary and secondary prevention, according to scientific evidence but adapted to the local situation with particular attention to regions with the highest burden of disease.</div>
</front>
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<li>Afrique du Sud</li>
<li>Australie</li>
<li>Belgique</li>
<li>Espagne</li>
<li>France</li>
<li>Israël</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>République populaire de Chine</li>
<li>États-Unis</li>
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<li>Auvergne-Rhône-Alpes</li>
<li>Californie</li>
<li>Catalogne</li>
<li>Floride</li>
<li>Géorgie (États-Unis)</li>
<li>Lombardie</li>
<li>Maryland</li>
<li>Piémont</li>
<li>Rhône-Alpes</li>
<li>Région de Bruxelles-Capitale</li>
<li>Île-de-France</li>
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<li>Barcelone</li>
<li>Bruxelles</li>
<li>Lyon</li>
<li>Milan</li>
<li>Paris</li>
<li>Pékin</li>
<li>Turin</li>
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<region name="Région de Bruxelles-Capitale">
<name sortKey="Arbyn, Marc" sort="Arbyn, Marc" uniqKey="Arbyn M" first="Marc" last="Arbyn">Marc Arbyn</name>
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<name sortKey="Arbyn, Marc" sort="Arbyn, Marc" uniqKey="Arbyn M" first="Marc" last="Arbyn">Marc Arbyn</name>
<name sortKey="Arbyn, Marc" sort="Arbyn, Marc" uniqKey="Arbyn M" first="Marc" last="Arbyn">Marc Arbyn</name>
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<name sortKey="Palefsky, Joel" sort="Palefsky, Joel" uniqKey="Palefsky J" first="Joel" last="Palefsky">Joel Palefsky</name>
<name sortKey="Wentzensen, Nicolas" sort="Wentzensen, Nicolas" uniqKey="Wentzensen N" first="Nicolas" last="Wentzensen">Nicolas Wentzensen</name>
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<name sortKey="Sideri, Mario" sort="Sideri, Mario" uniqKey="Sideri M" first="Mario" last="Sideri">Mario Sideri</name>
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<name sortKey="Lacey, Charles" sort="Lacey, Charles" uniqKey="Lacey C" first="Charles" last="Lacey">Charles Lacey</name>
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<name sortKey="Qiao, You In" sort="Qiao, You In" uniqKey="Qiao Y" first="You-Lin" last="Qiao">You-Lin Qiao</name>
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<name sortKey="Bornstein, Jacob" sort="Bornstein, Jacob" uniqKey="Bornstein J" first="Jacob" last="Bornstein">Jacob Bornstein</name>
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<name sortKey="Tommasino, Massimo" sort="Tommasino, Massimo" uniqKey="Tommasino M" first="Massimo" last="Tommasino">Massimo Tommasino</name>
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